Name Surname:
Şule Ünal Cangül
Title:
Prof.Md.
Department:
Hematology
Contact:
(312) 305 11 72
Assoc. Prof. Sule Unal
Dr Unal graduated from Hacettepe University Faculty of Medicine (English) in 1999. She received her speciality in Child Health and Diseases in 2005 and completed sub-specialiity in Pediatric Hematology in 2010. She became Assoc. Prof. of Pediatrics in 2011. She has ECFMG, TOEFL, Strategic Planning, Improvement Teams Guide Training certifications. In 2003-2004, she worked as the Chief Intern of Pediatrics, executive board member of Hacettepe Association of Improving and Supporting Pediatrics Education and executive board member of Katkı Pediatrics Journal. She is currently the President of Association of Congenital Blood Disorders, Treatment and Support and a member of Scientific Boardin Thalassemia Federation. In 2009, she had clinical and laboratory experience in Texas Children's Hospital. She made countryservice in Antakya State Hospital between 2011 and 2012. She has Young Investigator, Novartis Industry, Bayer-Schering Industry and TSH-TURKBA Awards. She is currently the assistant editor of Turkish Journal of Hematology and Managing Editor of Acta Medica. In 2015 she was awarded with International Development and Education award given bu American Society of Clinical Oncology (ASCO). Her professional interest is Pediatric Hematology field.Uluslararası hakemli dergilerde yayınlanan makaleler
1.Unal S,Kalkanoglu HS, Kocaefe C, Gucer S, Ozen S, Turanli G, Coskun T. Four-month-old infant with focal segmental glomerulosclerosis and mitochondrial DNA deletion. J Child Neurol. 2005;20:83-4.
2.Unal S,Yetgin S, Kara A, Kanra G. Autoimmune thrombocytopenic purpura after mumps infection. Turkish Journal of Pediatrics. 2005;47:270-1.
3.Kuskonmaz B,Unal S,Gumruk F, Cetin M, Tuncer AM, Gurgey A. The neurologic complications in pediatric acute lymphoblastic leukemia patients excluding leukemic infiltration. Leuk Res. 2006;30:537-41.
4.Kanra G, Cetin M,Unal S,Haliloglu G, Akca T, Akalan N, Kara A. Answer to hypotonia: A simple hemogram. J Child Neurol. 2005;20:930-1.
5.Sarici SU, Yurdakok M,Unal S.Acute gastric dilatation complicating the use of mydriatics in a preterm newborn. Pediatri Radiol. 2001;31:581-583.6.Gucer S, Talim B, Asan E, Korkusuz P, Ozen S,Unal S,Kalkanoglu SH, Kale G, Caglar M. Focal Segmental Glomerulosclerosis Associated with Mitochondrial Cytopathy: Report of Two Cases with Special Emphasis on Podocytes. Pediatr Dev Pathol. 2005;8:710-7.
7.Unal S,Gumruk F. Fanconi Anemia Patient With Bilaterally Hypoplastic Scapula and
Unilateral Winging Associated With Scoliosis and Rib Abnormality. J Pediatr Hematol Oncol. 2006;28:616-7.
8.Unal S, Fidan G, Tavil B, Cetin M, Cetinkaya DU. Allogeneic hematopoietic stem cell transplantation in pediatric chronic myelogenous leukemia cases: Hacettepe experience. Pediatr Transplant. 2007;11:645-9.
9.Unal S,Bayrakci B, Yasar U, Karagoz T. Successful treatment of propafenone, digoxin and warfarin overdosage with plasma exchange therapy and rifampicin. Clin Drug Investig. 2007;27:505-8.
10.Tavil B, Cetin M, Tuncer M, Gumruk F, Yuce A, Demir H, Aytac S, Kuskonmaz B,Unal S,Yetgin S. The rate of hepatitis B and C virus infections and the importance of HBV vaccination in children with acute lymphoblastic leukemia. Hepatol Res. 2007;37:498-502.
11.Uckan-Cetinkaya D,Unal S,Cetin M, Sarikabadayi U, Aktas D, Koc Y. Splenectomy status of the patient may have impact on response to donor lymphocyte infusions. Leukemia. 2007;21:2049-50.
12.Unal S,Cetin M, Tavil B, Caliskan N, Yetgin S, Uckan D. Favorable Outcome with Allogeneic Hematopoetic Stem Cell Transplantation in Pediatric Acquired Aplastic Anemia Patients. Pediatric Transplant. 2007;11:788-91.
13.Tavil B, Calıskan U,Unal S,Gumruk F. Pulmonary tuberculosis presented with pancytopenia, hemophagocytosis, and foamy histiocytes in an infant. Int J Tuberc Lung Dis. 2007;11:931-2.
14.Unal S,Gucer S, Kale G, Besbas N, Ozan S, Gumruk F. Severe Henoch-Schönlein Purpura in a Thalassemic Patient under Deferiprone Treatment. Am J Hematol. 2008;83:165-6.
15.Tavil B,Unal S,Aytaç-Elmas S, Yetgin S. Weekly long-term intravenous immunoglobulin for refractory parvovirus B19 and Epstein-Barr virus-induced immune thrombocytopenic purpura. Turk J Pediatr. 2008;50:74-7.
16.Tavil B, Seçmeer G, Ozen H, Cengiz AB,Unal S,Gürgey A. Foamy histiocytes in a patient with visceral leishmaniasis after treatment with liposomal amphotericin B. Turk J Pediatr. 2008;50:67-9.
17.Okur H, Balta G, Akarsu N, Oner A, Patiroglu T, Bay A, Sayli T,Unal S,Gurgey A.
Clinical and molecular aspects of Turkish familial hemophagocytic lymphohistiocytosis patients with perforin mutations. Leuk Res. 2008;32:972-5.
18.Kuskonmaz B,Unal S,Cördükcü E, Aydin H, Coskun T, Gurgey A, Gumruk F. Lymphocytic vacuolization in sialic acid storage disease. Am J Hematol. 2008;83:821.
19.Bayrakci B,Unal S,Erkocoglu M, Güngör HY, Aksu S. Case reports of successful therapeutic plasma exchange in severe amitriptyline poisoning. Ther Apher Dial. 2007;11:452-4.
20.Hazirolan T, Akpinar B,Unal S,Gümrük F, Haliloglu M, Alibek S.Value of Dual Energy Computed Tomography for detection of myocardial iron deposition in Thalassaemia patients: Initial experience. Eur J Radiol. 2008;68:442-5.
21.Yetgin S, Aslan D,Unal S,Tavil B, Kuşkonmaz B, Elmas SA, Olcay L, Cetinkaya DU. Dysplasia and disorder of cell membrane entirety in iron-deficiency anemia. Pediatr Hematol Oncol. 2008;25:492-501.
22.Balci YI,Unal S,Gumruk F, Cetin M, Ozkutlu S, Gurgey A. Nonstroke arterial thrombosis in children: Hacettepe experience. Blood Coagul Fibrinolysis. 2008;19:519-24.
23.Unal S,Durmaz E, Erkoçoğlu M, Bayrakçi B, Bircan O, Alikaşifoğlu A, Cetin M. The rapid correction of hypercalcemia at presentation of acute lymphoblastic leukemia using high-dose methylprednisolone. Turk J Pediatr. 2008;50:171-5.
24.Kuijpers TW, van de Vijver E, Weterman MA, de Boer M, Tool AT, van den Berg TK, Moser M, Jakobs ME, Seeger K, Sanal O,Unal S,Cetin M, Roos D, Verhoeven AJ, Baas F. LAD-1/variant syndrome is caused by mutations in FERMT3. Blood. 2009;113:4740-6.
25.Oner AF, Okur H, Balta G,Unal S,Deger I, Akarsu N, Gurgey A. Disease causing nature of homozygous missense, p.A523D, alteration in the perforin gene. Leuk Res. 2009;33(9):e152-3.
26.Unal S,Cerosaletti K, Uckan-Cetinkaya D, Cetin M, Gumruk F. A novel mutation in a family with DNA ligase IV deficiency syndrome. Pediatr Blood Cancer. 2009;53:482-4.
27.Unal S,Cakir M, Kuşkonmaz B, Cetin M, Tuncer AM. Successful treatment with gemtuzumab ozogamicin monotherapy in a pediatric patient with resistant relapse of acute myeloid leukemia. Turk J Pediatr. 2009;51:69-71.
28.Unal S,Tuncer AM, Cetin M, Yetgin S. The absence of peripheral blood blasts at diagnosis may predict CNS involvement or CNS relapse in pediatric acute lymphoblastic leukemia patients. Turk J Pediatr. 2008;50:537-41.
29.Unal S,Cetin M, Tuncer AM, Gümrük F, Yetgin S. The prognostic impact of myeloid antigen expression in pediatric acute lymphoblastic leukemia patients. Turk J Pediatr. 2008;50:533-6.
30.Gurgey A,Unal S,Okur H, Orhan D, Yurdakok M. Neonatal primary hemophagocytic lymphohistiocytosis in Turkish children. J Pediatr Hematol Oncol. 2008;30:871-6.
31.Unal S,Cetin M, Kutlay NY, Elmas SA, Gumruk F, Tukun A, Tuncer M, Gurgey A. Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemia. Ann Hematol. 2009 Oct 2. [Epub]
32.Celkan T, Berrak S, Kazanci E, Ozyürek E,Unal S,Uçar C, Yilmaz S, Gürgey A. Malignancy-associated hemophagocytic lymphohistiocytosis in pediatric cases: a multicenter study from Turkey. Turk J Pediatr. 2009;51:207-13.
33.Türkkani-Asal G, Alanay Y, Turul-Ozgür T, Zenker M, Thiel C, Rauch A, Unal S, Gürgey A, Tezcan I. Mild clinical phenotype and subtle radiographic findings in an infant with cartilage-hair hypoplasia. Turk J Pediatr. 2009;5:493-6.
34.Hazirolan T, Eldem G, Unal S, Akpinar B, Gümrük F, Alibek S, Haliloğlu M. Dual-echo TFE MRI for the assessment of myocardial iron overload in beta-thalassemia major patients. Diagn Interv Radiol. 2010;16:59-62.
35.Bajin IY, Ayvaz DC, Unal S, Ozgür TT, Cetin M, Gümrük F, Tezcan I, de Villartay JP, Sanal O. Atypical combined immunodeficiency due to Artemis defect: A case presenting as hyperimmunoglobulin M syndrome and with LGLL. Mol Immunol. 2013;56:354-357.
36.Celik HT, Günbey C, Unal S, Gümrük F, Yurdakök M. Glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinaemia: Hacettepe experıence. J Paediatr Child Health. 2013 May;49(5):399-402.
37.Gokce M, Aytac S, Altan I, Unal S, Tuncer M, Gumruk F, Cetin M. Intracerebral metastasis in pediatric acute lymphoblastic leukemia: A rare presentation. J Pediatr Neurosci. 2012;7(3):208-10.
38.Gokce M, Balta G, Unal S, Oguz K, Cetin M, Gumruk F. Spinal cord involvement in a child with familial hemophagocytic lymphohistiocytosis. J Pediatr Neurosci. 2012 Sep;7(3):194-6.
39.Chiang SC, Theorell J, Entesarian M, Meeths M, Mastafa M, Al-Herz W, Frisk P, Gilmour KC, Ifversen M, Langenskiöld C, Machaczka M, Naqvi A, Payne J, Perez-Martinez A, Sabel M, Unal E, Unal S, Winiarski J, Nordenskjöld M, Ljunggren HG, Henter JI, Bryceson YT. Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production. Blood. 2013;121:1345-56.
40.Unal S, Balta G, Okur H, Aytac S, Cetin M, Gumruk F, Ozen S, Gurgey A. Recurrent macrophage activation syndrome associated with heterozygous perforin W374X gene mutation in a child with systemic juvenile idiopathic arthritis. J Pediatr Hematol Oncol. 2013 ;35:e205-8.
41.Gokce M, Altan I, Unal S, Kuskonmaz B, Aytac S, Cetin M, Tuncer M, Gumruk F, Gurgey A. Recurrent pediatric thrombosis: the effect of underlying and/or coexisting factors. Blood Coagul Fibrinolysis. 2012;23:434-9.
42.Kılıç E, Utine E, Unal S, Haliloğlu G, Oğuz KK, Cetin M, Boduroğlu K, Alanay Y. Medical management of moyamoya disease and recurrent stroke in an infant with Majewski osteodysplastic primordial dwarfism type II (MOPD II). Eur J Pediatr. 2012;171:1567-71.
43.Gökçe M, Unal S, Gülşen H, Başaran O, Cetin M, Gümrük F, Beşbaş N, Gürgey A. A rare metabolic complication of acute lymphoblastic leukemia in childhood: lactic acidosis. Turk J Pediatr. 2012;54:61-3.
44.Aydinok Y, Unal S, Oymak Y, Vergin C, Türker ZD, Yildiz D, Yesilipek A. Observational study comparing long-term safety and efficacy of Deferasirox with Desferrioxamine therapy in chelation-naïve children with transfusional iron overload. Eur J Haematol. 2012;88:431-8.
45.Gokce M, Unal S, Bayrakçı B, Tuncer M. Chronic myeloid leukemia presenting with visual and auditory impairment in an adolescent: an insight to management strategies. Indian J Hematol Blood Transfus. 2010;26:96-8.
46.Gökçe M, Sahiner U, Unal S, Parlakay A, Oncel I, Saçkesen C, Kara A, Gümrük F. An unexpected parasitic cause of hypereosinophilia: fascioliasis. Turk J Pediatr. 2011;53:111-3.
47.Unal S, Gökçe M, Aytaç-Elmas S, Karabulut E, Altan I, Ozkaya-Parlakay A, Kara A, Ceyhan M, Cengiz AB, Tuncer M, Cetin M, Gümrük F. Hematological consequences of pandemic influenza H1N1 infection: a single center experience. Turk J Pediatr. 2010 Nov- ;52:570-5.
48.Unal S, Hazirolan T, Eldem G, Gumruk F. The effects of deferasirox on renal, cardiac and hepatic iron load in patients with β-thalassemia major: preliminary results. Pediatr Hematol Oncol. 2011 Apr;28(3):217-21.
49.Yalçin SS, Güneş B, Unal S, Gümrük F, Coşkun T. Antihyperlipidemic agents cause a decrease in von Willebrand factor levels in pediatric patients with familial hyperlipidemia. J Pediatr Endocrinol Metab. 2010 Aug;23(8):765-71.
50.Sule U, Muge G, Selin AE, Murat T, Mualla C, Fatma G. Mild to fatal course of pandemic influenza H1N1 in children with acute leukaemia. Br J Haematol. 2011 Feb;152(4):492-3.
Tavil B, Aytac S, Balci YI, Unal S, Kuskonmaz B, Yetgin S, Gurgey A, Tuncer M, Gumruk F, Uckan D, Cetin M. Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin (FLAG-IDA) for the treatment of children with poor-prognosis acute leukemia: the Hacettepe experience. Pediatr Hematol Oncol. 2010 Oct;27(7):517-28.
51.Unal S, Kuskonmaz B, Hazirolan T, Eldem G, Aytac S, Cetin M, Uckan D, Gumruk F. Deferasirox use after hematopoietic stem cell transplantation in pediatric patients with beta-thalassemia major: preliminary results. Pediatr Hematol Oncol. 2010;27:482-9.
52.Unal S, Kara F, Ozen S, Orhan D, Tuncer M, Gumruk F. Stanozolol treatment for successful prevention of attacks of severe primary cryofibrinogenemia. Pediatr Blood Cancer. 2010;15;55:174-6.
53.Balta G, Okur H, Unal S, Yarali N, Gunes AM, Unal S, Turker M, Guler E, Ertem M, Albayrak M, Patiroglu T, Gurgey A. Assessment of clinical and laboratory presentations of familial hemophagocytic lymphohistiocytosis patients with homozygous W374X mutation. Leuk Res. 2010 ;34:1012-7.
54. Unal S, Sag E, Kuskonmaz B, Kesici S, Bayrakci B, Ayvaz DC, Tezcan I, Yalnızoglu D, Uckan D. Successful treatment of severe myasthenia gravis developed after allogeneic hematopoietic stem cell transplantation with plasma exchange and rituximab. Pediatr Blood Cancer. 2013 Oct 18. doi: 10.1002/pbc.24799.
55. Unal S, Gumruk F, Yigit S, Tuncer M, Tavil B, Cil O, Takci S, Urata M, Hotta T, Kang D, Cetin M. A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period. Pediatr Blood Cancer. 2013 Sep 20. doi: 10.1002/pbc.24782.
56. Metin A, Unal S, Gümrük F, Palla R, Cairo A, Underwood M, Gurgey A. Congenital thrombotic thrombocytopenic purpura with novel mutations in three unrelated turkish children. Pediatr Blood Cancer. 2013 Sep 30. doi: 10.1002/pbc.24764.
57. Ekinci O, Celik T, Ünal Ş, Oktay G, Toros F, Ozer C. Nocturnal enuresis in sickle cell disease and thalassemia major: associated factors in a clinical sample. Int J Hematol. 2013 Oct;98(4):430-6. doi: 10.1007/s12185-013-1422-9. Epub 2013 Sep 8.
58. Bajin İY, Ayvaz DÇ, Ünal S, Özgür TT, Çetin M, Gümrük F, Tezcan İ, de Villartay JP, Sanal Ö. Atypical combined immunodeficiency due to Artemis defect: a case presenting as hyperimmunoglobulin M syndrome and with LGLL. Mol Immunol. 2013 Dec;56(4):354-7. doi: 10.1016/j.molimm.2013.05.004.
59. Chiang SC, Theorell J, Entesarian M, Meeths M, Mastafa M, Al-Herz W, Frisk P, Gilmour KC, Ifversen M, Langenskiöld C, Machaczka M, Naqvi A, Payne J, Perez-Martinez A, Sabel M, Unal E, Unal S, Winiarski J, Nordenskjöld M, Ljunggren HG, Henter JI, Bryceson YT. Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production. Blood. 2013 Feb 21;121(8):1345-56. doi: 10.1182/blood-2012-07-442558.
60. Unal S, Balta G, Okur H, Aytac S, Cetin M, Gumruk F, Ozen S, Gurgey A. Recurrent macrophage activation syndrome associated with heterozygous perforin W374X gene mutation in a child with systemic juvenile idiopathic arthritis. J Pediatr Hematol Oncol. 2013 Jul;35(5):e205-8. doi: 10.1097/MPH.0b013e31827b4859.
61. van de Vijver E, Tool AT, Sanal O, Cetin M, Unal S, Aytac S, Seeger K, Pagliara D, Rutella S, van den Berg TK, Kuijpers TW. Kindlin-3-independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III.J Allergy Clin Immunol. 2013 Dec 13. pii: S0091-6749(13)01632-1. doi: 10.1016/j.jaci.2013.10.020.
62. Unal S, Alanay Y, Cetin M, Boduroglu K, Utine E, Cormier-Daire V, Huber C, Ozsurekci Y, Kilic E, Simsek Kiper OP, Gumruk F. Striking hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II (MOPD II): A potential role of pericentrin in hematopoiesis.Pediatr Blood Cancer. 2014 Feb;61(2):302-5.
Childhood hematological disorders.
| High School |
|
|||||||||
| Univercity |
|
|||||||||
| Academic Background |
|
|||||||||
| Foreign Experience / Education | In 2009, had clinical and laboratory experience in Texas Children's Hospital, USA. | |||||||||
| Foreign Language | english |
: (312) 305 11 72
: suleunal@hacettepe.edu.tr